Henry, who entered the game with 1,777 yards rushing, ran for a career-high 250 yards to lead the Tennessee Titans to a 41-38 victory over the Houston Texans to win their first AFC South title since 2008.
Henry finished the season with 2,027 rushing yards, which is the fifth-best rushing total in a season. He’s the first player to accomplish the feat since Adrian Peterson had 2,097 in 2012.
Rookie kicker Sam Sloman knocked in a 37-yard field goal that bounced off the upright to give the Titans the win as time expired.
Tannehill threw for 216 yards and a touchdown and ran for two more scores.
The Titans will host the Baltimore Ravens in the wild-card round of the playoffs next weekend.
Indianapolis will travel to Buffalo, and Cleveland will visit Pittsburgh to round out the remaining playoff games in the AFC.